python-用.replace命令一次替换多个字符

有没有办法用单个字符替换多个不同的字符 .更换 命令?

目前,我每行或通过一个循环执行一次:

    UserName = input("Enter in Username:")
    UserName = UserName.replace("/", "_")
    UserName = UserName.replace("?", "_")
    UserName = UserName.replace("|", "_")
    UserName = UserName.replace(":", "_")
    print(UserName)

    #Here's the second way- through a loop.
    Word = input("Enter in Example Word: ")
    ReplaceCharsList = list(input("Enter in replaced characters:"))

    for i in range(len(ReplaceCharsList)):
        Word = Word.replace(ReplaceCharsList[i],"X")
    print(Word)

有没有 更好的 怎么做?